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- McDonald Observatory
- McDonnell Douglas
- M cells
- McFadden, Daniel Little (1937– )
- McFadden’s R2
- McGuinness, Martin (1950–2017)
- McIntosh scheme
- McKinley, William (1843–1901)
- McKinsey axiom
- McKusick, Victor Almon
- McLeod gauge
- MCLs
- MCLV
- McMahon Line
- McMahon, Sir William (1908–88)
- McMath–Pierce Solar Telescope
- MCMC
- McMillan, Edwin Mattison
- McMillan–Mayer theory
- McMonagle, Donald Ray (1952– )
- McNair, Ronald E (1950–86)
- McNaught, Comet
- McNemar, Quinn (1900–86)
- McNemar test
- M-commerce
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