He practised psychiatry in Sarajevo until 1990, when he helped found the Serbian Democratic Party. In 1992, when the Bosnian Serbs declared an independent state, the Republika Srpska, within Bosnia and Herzegovina, Karadžić became its President. With the support of Serbian President Slobodan Milošević, he instituted a ruthless campaign (1992–95) to drive non-Serb Bosnians from the republic. In 1995, when Milošević withdrew support, Karadžić reluctantly signed the US-brokered Dayton peace accord. Twice that year he was indicted by the UN for war crimes, including ‘ethnic cleansing’. He resigned as President of both the Republika Srpska and the Serbian Democratic Party in 1996 and went into hiding, successfully managing to evade arrest until 2008. His trial before the International Criminal Tribunal for the former Yugoslavia began in 2009. In 2016 he was found guilty of genocide, multiple counts of war crimes, and crimes against humanity, and sentenced to 40 years in prison.