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单词 bioreactor
释义
bioreactor

Chemistry
  • A large stainless steel tank used to grow producer microorganisms in the industrial production of enzymes and other chemicals. After the tank is steam-sterilized, an inoculum of the producer cells is introduced into a medium that is maintained by probes at optimum conditions of temperature, pressure, pH, and oxygen levels for enzyme production. An agitator (stirrer) mixes the medium, which is constantly aerated. It is essential that the culture medium is sterile and contains the appropriate nutritional requirements for the microorganism. When the nutrients have been utilized the product is separated; if the product is an extracellular compound the medium can be removed during the growth phase of the microorganisms, but an intracellular product must be harvested when the batch culture growth stops. Some bioreactors are designed for continuous culture.


Chemical Engineering
  • A vessel used for biological processing containing the growth of living cells or tissues, either as the product themselves or as biocatalysts in the production of other products. There are many designs of bioreactors. The most common are cylindrical and range in capacity from a few litres to many cubic metres. Small bioreactors are made of glass while large bioreactors are fabricated from stainless steel.

    The biological processes contained within the bioreactor may be in the form of a suspension of cells or immobilized, and depending on the living organism, operated aerobically or anaerobically. The mode of operation is batch, fed batch, or continuous. An example of a continuously operated bioreactor is the chemostat.

    Constant agitation within a bioreactor can be maintained with an appropriate stirrer which also aids oxygen transfer in aerobic processes. Low-speed impellers or the use of sparged air up draft tubes are typically used to aid mixing. Since all bioprocesses are exothermic, cooling is required using either an external jacket or, for very large vessels, internal cooling coils.


Biology
  • A large stainless steel tank used to grow producer microorganisms in the industrial production of enzymes and other chemicals. After the tank is steam-sterilized, an inoculum of the producer cells is introduced into a medium that is maintained by probes at optimum conditions of temperature, pressure, pH, and oxygen levels for enzyme production. An agitator mixes the medium, which is constantly aerated. It is essential that the culture medium is sterile and contains the appropriate nutritional requirements for the microorganism. When the nutrients have been utilized the product is separated; if the product is an extracellular compound the medium can be removed during the growth phase of the microorganisms, but an intracellular product must be harvested when the batch culture growth stops. Some bioreactors are designed for continuous culture.


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