A double-reciprocal plot used to determine the two constants featured in simple enzyme kinetic equations such as Michaelis–Menten kinetics, Monod kinetics, and in similar adsorption isotherm models such as the Langmuir adsorption isotherm. The constants are determined from the intercept with the y-axis and the gradient (see Fig. 26). It was devised and published in 1934 by American chemist Hans Lineweaver (1907–2009) and American biochemist Dean Burk (1904–1988).