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单词 Knoevenagel reaction
释义
Knoevenagel reaction

Chemistry
  • A reaction in which an aldehyde RCHO reacts with malonic acid (CH2(COOH)2) with subsequent loss of CO2 to give an unsaturated carboxylic acid RCH=CHCOOH. Thus, the chain length is increased by 2. The reaction is base-catalysed; usually pyridine is used. The reaction is named after Emil Knoevenagel (1865–1921), who discovered it in 1898.


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