“anti-CD70 monoclonal antibody MDX-1411”的概念、定义、翻译、参考文献-科学参考

单词	anti-CD70 monoclonal antibody MDX-1411
释义	anti-CD70 monoclonal antibody MDX-1411 A glycoengineered, fully humanized IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Anti-CD70 fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types. Check for active clinical trialsusing this agent.
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