A drug used to treat locally advanced basal cell carcinoma (BCC) that has come back after surgery or radiation therapy. It is also used in patients who cannot be treated with surgery or radiation therapy. LDE225 is also being studied in the treatment of other types of cancer. LDE225 blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of hedgehog signaling pathway antagonist. Also called erismodegib, Odomzo, and sonidegib.