“amsacrine”的概念、定义、翻译、参考文献-科学参考

An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis. or An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.

单词	amsacrine
释义	amsacrine An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis. or An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
随便看	stereoisomer stereoscopic vision stereotactic biopsy stereotactic body radiation therapy stereotactic external-beam radiation therapy stereotactic injection stereotactic radiation therapy stereotactic radiosurgery stereotaxic radiation therapy stereotaxic radiosurgery stereotaxis sterile Sterile Talc Powder sterile talc powder Steritalc sternum steroid steroid cream steroid drug steroid metabolism gene steroids steroid sulfatase inhibitor BN 83495 steroid therapy STI571 stigma