A drug used to treat progressive medullary thyroid cancer that has spread to other parts of the body. It is also being studied in the treatment of other types of cancer. Cometriq blocks certain proteins, which may help keep cancer cells from growing. It may also prevent the growth of new blood vessels that tumors need to grow. Cometriq contains the active ingredient cabozantinib-s-malate. It is a type of tyrosine kinase inhibitor and a type of angiogenesis inhibitor.