单词 | B-Raf/VEGFR-2 inhibitor RAF265 |
释义 | B-Raf/VEGFR-2 inhibitor RAF265 An orally bioavailable small molecule with potential antineoplastic activity. B-Raf/VEGFR-2 inhibitor RAF265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. |
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