Cancer (1) has spread beyond the seminal vesicles to nearby tissue or organs, such as the rectum, bladder, or pelvic wall; or (2) has spread to nearby lymph nodes and may have spread to the seminal vesicles or to nearby tissue or organs, such as the rectum, bladder, or pelvic wall; or (3) has spread to distant parts of the body, which may include lymph nodes or bones. Also, the prostate-specific antigen (PSA) can be any level and the Gleason score can range from 2 to 10.