释义 |
pazopanib hydrochloride The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. or A chemotherapy combination used to treat endometrial, ovarian, and head and neck cancers, and non-small cell lung cancer that has spread. It includes the drugs carboplatin and paclitaxel (Taxol). Also called Carbo-Tax regimen, carboplatin-Taxol, carboplatin-Taxol regimen, and CaT regimen. |