“ortataxel”的概念、定义、翻译、参考文献-科学参考

A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in the inhibition of cell division and cellular proliferation. As it represents a poor substrate for P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1 and BCRP.

单词	ortataxel
释义	ortataxel A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in the inhibition of cell division and cellular proliferation. As it represents a poor substrate for P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1 and BCRP.
随便看	cytokeratin cytokine cytokine-induced killer cells cytokines cytokinesis cytokinin cytology cytomegalovirus cytomegalovirus IE-1-specific cytotoxic T lymphocytes cytomegalovirus pp65-specific cytotoxic T lymphocytes Cytomel cytopenia cytoplasm cytoplasm cytoplasmic determinants cytoplasmic streaming Cytosar-U cytosine cytoskeleton cytosol cytostatic agent cytotoxic agent cytotoxic chemotherapy cytotoxic T cell cytotoxic T cell (TC)