请输入您要查询的字词:

 

单词 thymocyte
释义
thymocyte

Biology
  • An immature or developing lymphocyte in the thymus that is the forerunner of a T cell. Progenitor cells enter the thymus from bone marrow to become thymocytes, which proliferate and undergo distinct developmental stages marked by changes in their CD surface proteins (see cd). During maturation they express on their surface a precursor T-cell receptor (pre-T-cell receptor) and both CD8 and CD4 proteins (double-positive cells). At the same time they slowly migrate from the outer cortex of the thymus to the inner medullary region. Some 98% of thymocytes express surface receptors that fail to recognize self antigen, and these cells undergo apoptosis and die; only the 2% of cells capable of distinguishing self antigen survive to maturity in the medulla. Here they become single-positive cells, expressing exclusively CD4 or CD8 surface proteins, and are exported from the thymus in the bloodstream to become helper T cells and cytotoxic T cells, respectively. See also somatic recombination.


随便看

 

科学参考收录了60776条科技类词条,基本涵盖了常见科技类参考文献及英语词汇的翻译,是科学学习和研究的有利工具。

 

Copyright © 2000-2023 Sciref.net All Rights Reserved
京ICP备2021023879号 更新时间:2025/2/6 0:07:08