1. The process of destroying microorganisms that contaminate food, wounds, surgical instruments, etc. Common methods of sterilization include heat treatment (see autoclave; pasteurization) and the use of disinfectants and antiseptics.
2. The operation of making an animal or human incapable of producing offspring. Men are usually sterilized by tying and then cutting the vas deferens (vasectomy); in women the operation often involves permanently blocking the fallopian tubes by means of clips (tubal occlusion). See also birth control.