A graphical method used in enzyme kinetics to obtain a straight line from experimental data. It involves forming a plot of V/S versus V in which S is the substrate concentration at which the velocity v is observed. The gradient of the line is equal to −K_m and the intercept on the y-axis is equal to the maximum velocity V. Also known as the Eadie–Hofstee plot, it is named after Canadian biochemist George Sharp Eadie (1895–1976) and B. H. J. Hofstee who developed the plot in 1942 and 1959, respectively. See michaelis-menten kinetics.