The techniques involved in altering the characters of an organism by modifying its genome. This can mean changing the base sequence of its DNA in some way, e.g. by knockout or genome editing, or inserting genes from another organism to create recombinant DNA. Alternatively, entirely new genes can be assembled from scratch using sequence information and DNA synthesizers to code for proteins with particular desired properties (see synthetic biology). Bacteria or yeasts containing the recombinant genes serve as ‘cellular factories’, synthesizing the desired protein. Genetic engineering has many applications, ranging from the commercial production of insulin and other hormones, vaccines, etc., to the creation of transgenic animals and crop plants in agriculture (see genetically modified organisms). See also dna library; dna probe; gene cloning; gene therapy; monoclonal antibody.