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药物体内哺乳动物细胞微核试验
释义
药物体内哺乳动物细胞微核试验
Encyclopedia
医学
药物体内哺乳动物细胞微核试验
释
in vivo mammalian cell micronucleus test
药物体内哺乳动物细胞微核试验
一种体内遗传毒性试验方法,可用于药物遗传毒性评价,其检测终点是染色体损伤。哺乳动物体内微核试验用于通过分析动物(通常为啮齿类动物,如小鼠或大鼠)的骨髓红细胞或外周血细胞中未成熟红细胞或新生网织红细胞中的微核率,来检测受试物对染色体的损伤。
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