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毒性机制
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毒性机制
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毒理学
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toxic mechanism
毒性机制
物理、化学、生物等外源因素作用于机体,对其生物学结构、代谢和功能产生毒性效应时,定性和定量地阐述导致毒效应的外源因素与机体相互作用过程、机体应答、各种信号通路和内在本质原因。即明确毒物是如何进入机体,如何与靶组织器官、靶分子交互作用、如何损伤机体,而机体又是如何应答损伤的一系列内在事件。
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