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机制性抑制
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机制性抑制
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医学
机制性抑制
释
mechanism-based inhibition; MBI
机制性抑制
一些抑制剂经细胞色素P450酶系(cytochrome p450 enzyme system; CYP450s)代谢形成活性中间产物,后者与CYP450s牢固结合,导致短暂性酶失活;或与酶发生共价结合,导致酶永久性失活的现象。又称时间依赖性抑制(time dependent inhibition; TDI)。
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