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抗体依赖性细胞介导的细胞毒作用
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抗体依赖性细胞介导的细胞毒作用
Encyclopedia
医学
抗体
释
antibody dependent cell mediated cytotoxicity,ADCC
抗体依赖性细胞介导的细胞毒作用
当抗体的抗原结合片段(Fab段)与病毒感染的细胞或肿瘤细胞表面的抗原结合后,抗体的可结晶片段(Fc段)与自然杀伤细胞(NK细胞)、巨噬细胞、中性粒细胞等效应细胞上表达的Fcγ受体结合,介导NK细胞、巨噬细胞、中性粒细胞等效应细胞直接杀伤靶细胞的作用。
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