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T细胞阳性选择
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T细胞阳性选择
Encyclopedia
医学
T细胞发育
释
T cell positive selection/positive selection of T cells
T细胞阳性选择
在胸腺皮质中,未成熟的CD4+CD8+双阳性T细胞(DP细胞)所表达的T细胞受体(T cell receptor,TCR)与胸腺上皮细胞表面的自身抗原肽(主要组织相容性复合体Ⅰ类Ⅱ类或分子复合物)结合,诱导分化为成熟的CD4+或CD8+单阳性(single positive)T细胞(SP细胞)的过程。简称阳性选择。
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