“mechanism-based inhibition”的概念、定义、翻译、参考文献-科学参考

单词	mechanism-based inhibition
释义	mechanism-based inhibition Encyclopedia 医学机制性抑制释 mechanism-based inhibition; MBI机制性抑制一些抑制剂经细胞色素P450酶系（cytochrome p450 enzyme system; CYP450s）代谢形成活性中间产物，后者与CYP450s牢固结合，导致短暂性酶失活；或与酶发生共价结合，导致酶永久性失活的现象。又称时间依赖性抑制（time dependent inhibition; TDI）。
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