“oral azacitidine”的概念、定义、翻译、参考文献-科学参考

An orally bioavailable formulation of azacitidine, a pyrimidine nucleoside analogue of cytidine, with antineoplastic activity. Upon oral administration, azacitidine is taken up by cells and metabolized to 5-azadeoxycitidine triphosphate. The incorporation of 5-azadeoxycitidine triphosphate into DNA reversibly inhibits DNA methyltransferase, and blocks DNA methylation. Hypomethylation of DNA by azacitidine may re-activate tumor suppressor genes previously silenced by hypermethylation, resulting in an antitumor effect. In addition, the incorporation of 5-azacitidine triphosphate into RNA disrupts normal RNA function and impairs tRNA (cytosine-5)-methyltransferase activity, resulting in an inhibition of RNA and protein synthesis.

单词	oral azacitidine
释义	oral azacitidine An orally bioavailable formulation of azacitidine, a pyrimidine nucleoside analogue of cytidine, with antineoplastic activity. Upon oral administration, azacitidine is taken up by cells and metabolized to 5-azadeoxycitidine triphosphate. The incorporation of 5-azadeoxycitidine triphosphate into DNA reversibly inhibits DNA methyltransferase, and blocks DNA methylation. Hypomethylation of DNA by azacitidine may re-activate tumor suppressor genes previously silenced by hypermethylation, resulting in an antitumor effect. In addition, the incorporation of 5-azacitidine triphosphate into RNA disrupts normal RNA function and impairs tRNA (cytosine-5)-methyltransferase activity, resulting in an inhibition of RNA and protein synthesis.
随便看	optimism OptiPrep Optison Oracit oral oral aminolevulinic acid hydrochloride oral and maxillofacial surgeon oral azacitidine oral cancer oral cavity oral cavity cancer oral chemotherapy oral contraceptive pill Oralet oral fludarabine phosphate oral Hsp90 inhibitor IPI-493 oral microencapsulated diindolylmethane oral milataxel oral picoplatin oral rehydration solution oral sodium phenylbutyrate oral surgeon oral topotecan hydrochloride Oramorph Oramorph SR