A combination of two drugs used to prevent nausea and vomiting caused by chemotherapy. It is a combination of netupitant and palonosetron hydrochloride. Netupitant and palonosetron hydrochloride blocks the action of chemicals in the brain that may trigger nausea and vomiting. Netupitant and palonosetron hydrochloride is a type of antiemetic. Also called Akynzeo.