Genetic tests that use next-generation sequencing to test multiple genes simultaneously. Also called multigene test and multiple-gene test. orA laboratory test in which many genes are studied in a sample of tissue. Multiple-gene panel tests may help find mutations (changes) in certain genes that may increase a person’s risk of a disease such as cancer. They may also look at the activity of certain genes in a sample of tissue. Multiple-gene panel tests may be used to help plan treatment or make a prognosis, including helping to predict whether cancer will spread to other parts of the body or come back. Also called multigene test and multiple-gene test.