“MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine”的概念、定义、翻译、参考文献-科学参考

A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation.

单词	MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine
释义	MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation.
随便看	stage IV ovarian germ cell tumor stage IV ovarian low malignant potential tumor stage IV pancreatic cancer stage IV penile cancer stage IV perihilar extrahepatic bile duct cancer stage IV prostate cancer stage IV renal cell cancer stage IV salivary gland cancer stage IV Sezary syndrome stage IV soft tissue sarcoma stage IV thymoma stage IV transitional cell cancer of the renal pelvis and ureter stage I vulvar cancer stage IV uterine sarcoma stage IV vaginal cancer stage IV vulvar cancer stage IV Wilms tumor stage I Wilms tumor stage V Wilms tumor staging staging system Stakel stamen stamina standardized freeze-dried table grape powder