“liposomal eribulin mesylate”的概念、定义、翻译、参考文献-科学参考

A liposome-encapsulated formulation of the mesylate salt form of eribulin, a synthetic, macrocyclic ketone analogue of halichondrin B, a substance derived from the marine sponge genus Halichondria, with potential antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits both the polymerization of tubulin and the assembly of microtubules. This results in the inhibition of mitotic spindle assembly, the induction of cell cycle arrest at G2/M phase, as well as tumor cell apoptosis. Compared to the administration of eribulin alone, liposomal delivery of eribulin allows for a longer half-life, which allows increased drug concentration in target tissues while decreasing systemic toxicity.

单词	liposomal eribulin mesylate
释义	liposomal eribulin mesylate A liposome-encapsulated formulation of the mesylate salt form of eribulin, a synthetic, macrocyclic ketone analogue of halichondrin B, a substance derived from the marine sponge genus Halichondria, with potential antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits both the polymerization of tubulin and the assembly of microtubules. This results in the inhibition of mitotic spindle assembly, the induction of cell cycle arrest at G2/M phase, as well as tumor cell apoptosis. Compared to the administration of eribulin alone, liposomal delivery of eribulin allows for a longer half-life, which allows increased drug concentration in target tissues while decreasing systemic toxicity.
随便看	Halaven Haldol Half-life Half-Life Half-life half-life half-sibling hallucination Halodrin halofuginone hydrobromide halofuginone hydrobromide haloperidol Halotestin Halsted radical mastectomy hamartoma hand-foot syndrome haploid cell haploinsufficiency haplotype happy major hard palate Hardy-Weinberg equilibrium Hardy-Weinberg theorem Hashimoto disease Hashimoto thyroiditis