“HDAC inhibitor CHR-2845”的概念、定义、翻译、参考文献-科学参考

A hydroxamic acid-derived histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CHR-2845 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in chromatin remodeling, inhibition of tumor oncogene transcription, inhibition of tumor cell division, and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins; this agent may specifically target HDACs in cells of the monocyte-macrophage lineage.

单词	HDAC inhibitor CHR-2845
释义	HDAC inhibitor CHR-2845 A hydroxamic acid-derived histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CHR-2845 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in chromatin remodeling, inhibition of tumor oncogene transcription, inhibition of tumor cell division, and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins; this agent may specifically target HDACs in cells of the monocyte-macrophage lineage.
随便看	independent assortment independent variable Inderal indeterminate indeterminate cleavage indeterminate growth index case Index of refraction Indian cress Indian elm Indian rhubarb Indian saffron Indian valerian indibulin indication indicine-N-oxide indinavir indinavir sulfate indirect ophthalmoscopy Indium 111 ProstaScint indium In 111 anti-CD45 monoclonal antibody BC8 indium In 111 anti-CEA monoclonal antibody M5A indium In 111 anti-EGFR monoclonal antibody ABT-806 indium In 111 bevacizumab indium In 111 capromab pendetide