“GnRH antagonist TAK-385”的概念、定义、翻译、参考文献-科学参考

An orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. GnRH antagonist TAK-385 competitively binds to and blocks the GnRH receptor in the anterior pituitary gland, which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation.

单词	GnRH antagonist TAK-385
释义	GnRH antagonist TAK-385 An orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. GnRH antagonist TAK-385 competitively binds to and blocks the GnRH receptor in the anterior pituitary gland, which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation.
随便看	PARP inhibitor AZD2281 PARP inhibitor BGB-290 PARP inhibitor CEP-9722 PARP inhibitor E7016 parthenogenesis partial-breast irradiation partial cystectomy partial hysterectomy partial laryngectomy partial mastectomy partial nephrectomy partial oophorectomy partial pressures partial radical vulvectomy partial remission partial response partial vulvectomy ParvOryx parvovirus H-1 Pascal Pascal's law Paschen series pasireotide passive antibody therapy passive transport