(Other name for: topical fluorouracil) or A drug used to treat cancers of the breast, colon, rectum, stomach, and pancreas. Under the brand names Carac, Tolak, Efudex, and Fluoroplex, it is used as a cream to treat actinic keratosis (a skin condition that may become cancer). It is also used under the brand name Efudex as a cream to treat basal cell skin cancer that is superficial (not invasive) and cannot be removed by surgery. Fluoroplex is being studied in the treatment of other conditions and types of cancer. It stops cells from making DNA and may kill cancer cells. Fluoroplex is a type of antimetabolite. Also called 5-fluorouracil, 5-FU, Carac, Efudex, fluorouracil, and Tolak.