单词 | edotecarin |
释义 | edotecarin A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. or A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor. Also called J-107088. |
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