“E. coli CD-expressing genetically modified neural stem cells”的概念、定义、翻译、参考文献-科学参考

Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity.

单词	E. coli CD-expressing genetically modified neural stem cells
释义	E. coli CD-expressing genetically modified neural stem cells Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity.
随便看	netupitant and palonosetron hydrochloride Neugranin Neulasta Neulasta Neumega Neumega Neupogen Neuradiab neural neural crest neural groove neural plate neural tube neurobehavioral neuroblastoma neurocognitive neurodegenerative disorder neuroectodermal tumor neuroendocrine neuroendocrine carcinoma of the skin neuroendocrine tumor neuroepithelial neurofeedback neurofibroma neurofibromatosis type 1