“denileukin diftitox”的概念、定义、翻译、参考文献-科学参考

A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death.

单词	denileukin diftitox
释义	denileukin diftitox A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death.
随便看	matrix matrix metalloproteinase Matter Matter matter Matulane mature T-cell lymphoma mature teratoma matuzumab Maxalt Maxamine maxillary sinus maximum inspiratory pressure test maximum tolerated dose Maxipime Mayo Clinic regimen maytansine maytansinoid DM4-conjugated humanized monoclonal antibody huC242 m-azidopyrimethamine MBL MC1R MC5-A scrambler therapy MC-Glucan MCL-1 Inhibitor AMG 176 MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine