Treatment used to block androgen (male hormone) activity in the body. This may be done by giving an antiandrogen drug and removing the testicles (orchiectomy) or by giving an antiandrogen drug with a gonadotropin-releasing hormone (GnRH) agonist. Combined androgen blockade may stop the growth of cancer cells that need androgens to grow, and is used in the treatment of prostate cancer. Also called complete androgen blockade and total androgen blockade.