A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. OR A tube-shaped tobacco product that is made of tightly rolled, cured tobacco leaves in a tobacco leaf wrapper or a wrapper that contains tobacco. It may also have other ingredients, including substances to add different flavors. A cigar is lit on one end and smoked, but the smoke is usually not inhaled into the lungs. Cigars contain nicotine and many cancer-causing chemicals that are harmful to both smokers and nonsmokers. Smoking cigars can lead to nicotine addiction and can cause cancers of the mouth, larynx (voice box), esophagus, lung, and pancreas. Heavy cigar smoking can also increase the risk of heart disease and lung diseases, such as emphysema and chronic bronchitis.