“cidofovir”的概念、定义、翻译、参考文献-科学参考

A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.

单词	cidofovir
释义	cidofovir A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.
随便看	hypervascular hypha hypnosis hypofractionated radiation therapy hypofractionation hypogammaglobulinemia hypoglycemia hypomagnesemia hyponatremia hypopharyngeal cancer hypopharynx hypophosphatemia hypospadias hypotension hypothalamus Hypothesis hypothesis hypothyroidism hypotonic solution hypoxemia hypoxia hypoxia-activated prodrug TH-302 hypoxia-activated prodrug TH-4000 hypoxic Hypoxin