A drug used to treat advanced renal cell carcinoma (a type of kidney cancer) that was treated with antiangiogenesis therapy (a type of anticancer therapy). It is used under the brand name Cabometyx to treat this cancer. It is also used under the brand name Cometriq to treat progressive medullary thyroid cancer that has spread to other parts of the body. Cabozantinib-s-malate is also being studied in the treatment of other types of cancer. It blocks certain proteins, which may help keep cancer cells from growing. It may also prevent the growth of new blood vessels that tumors need to grow. Cabozantinib-s-malate is a type of tyrosine kinase inhibitor and a type of angiogenesis inhibitor.