A paste containing multiple skin protectants with anti-oxidant, skin protecting, moisturizing, anti-erythema and anti-inflammatory activities. The paste includes zinc oxide, aluminum starch octenylsuccinate, lanolin, allantoin, chamomile and sweet almond oil, rice bran oil, shea butter, dimethicone (polymerized siloxane), petrolatum, vitamin E, phytosome of glycyrrhetinic acid and botanical extracts derived from Calendula officinalis, Malva sylvestris and Tilia tomentosa. Upon application, this paste provides a physical barrier on the skin and may help protect, soothe and moisturize the skin as well as restore skin softness, integrity and elasticity. When this paste is applied to the perineum area, it may help prevent radiation-induced dermatitis.