“autologous EBV-CTL CD19CAR zeta”的概念、定义、翻译、参考文献-科学参考

Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.

单词	autologous EBV-CTL CD19CAR zeta
释义	autologous EBV-CTL CD19CAR zeta Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
随便看	intrapelvic intraperitoneal intraperitoneal chemotherapy intraperitoneal infusion intraperitoneal radiation therapy intrapleural intraspinal intrathecal intrathecal chemotherapy intratumoral intrauterine intrauterine device intravaginal intravasation intravenous intravenous chemotherapy intravenous infusion intravenous injection intravenous pyelogram intravenous pyelography intraventricular infusion intravesical intravitreal chemotherapy intrinsic rate of increase introgression