An autophagosome-enriched cancer vaccine composed of short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from tumor cells, with potential immunostimulating and antineoplastic activities. The Dribbles are DriPs- and SLiPs-filled autophagosomes that are made by treating cancer cells with both a proteasome inhibitor, to prevent protein degradation, and an autophagy inducer, which causes the accumulation of DriPs, SLiPs, and their immunogenic fragments. Upon administration of a Dribbles vaccine, the proteins or antigen fragments in Dribbles may stimulate the immune system to mount cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte responses against the cancer-associated antigens (TAAs).