“triptolide analogue”的概念、定义、翻译、参考文献-科学参考

A water soluble analogue of the diterpenoid triepoxide triptolide isolated from the Chinese herb Tripterygium wilfordii Hook F with potential antineoplastic activity. Upon intravenous administration, the triptolide analogue inhibits heat shock protein 70 (HSP70) and prevents HSP70-mediated inhibition of apoptosis. This leads to both the induction of apoptosis and a reduction of cancer cell growth. HSP70, a molecular chaperone upregulated in various cancer cells, plays a key role in the inhibition of caspase-dependent and -independent apoptosis.

单词	triptolide analogue
释义	triptolide analogue A water soluble analogue of the diterpenoid triepoxide triptolide isolated from the Chinese herb Tripterygium wilfordii Hook F with potential antineoplastic activity. Upon intravenous administration, the triptolide analogue inhibits heat shock protein 70 (HSP70) and prevents HSP70-mediated inhibition of apoptosis. This leads to both the induction of apoptosis and a reduction of cancer cell growth. HSP70, a molecular chaperone upregulated in various cancer cells, plays a key role in the inhibition of caspase-dependent and -independent apoptosis.
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