“topotecan hydrochloride”的概念、定义、翻译、参考文献-科学参考

The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

单词	topotecan hydrochloride
释义	topotecan hydrochloride The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.
随便看	condensation Condensation nuclei Condensation point Condensation point condensation reaction Condensation (sound) Condensation (water vapor) condition conditionally replicative adenovirus 5/3-delta24 conditioned response conditioned stimulus conditioning regimen Conduction Conduction condyloma cone biopsy cone cell conformation-sensitive gel electrophoresis confusion congenital congenital hemangioma congenital hypoplastic anemia congenital mesoblastic nephroma congenital neutropenia congenital pure red cell aplasia