“thymidylate synthase inhibitor DFP-11207”的概念、定义、翻译、参考文献-科学参考

单词	thymidylate synthase inhibitor DFP-11207
释义	thymidylate synthase inhibitor DFP-11207 An orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. Upon oral administration, DFP-11207 binds to and inhibits TS. This reduces thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA damage and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).
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