“TGFa-PE38 immunotoxin”的概念、定义、翻译、参考文献-科学参考

A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.

单词	TGFa-PE38 immunotoxin
释义	TGFa-PE38 immunotoxin A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.
随便看	nucleoside nucleoside analog DFP-10917 nucleosome Nucleosynthesis nucleotide nucleotide nucleotide analogue GS 9219 Nucleus Nucleus Nucleus nucleus Nucynta null allele null hypothesis Numorphan nurse nurse case manager nurse practitioner nursing home nutraceutical nutraceutical TBL-12 Nutracort NutreStore nutrient-dense food nutrient-rich whole wheat flour supplement