“STAT inhibitor OPB-111077”的概念、定义、翻译、参考文献-科学参考

An orally bioavailable inhibitor of one or more signal transducer and activator of transcription (STAT) protein(s), with potential antineoplastic activity. Upon oral administration, OPB-111077 binds to and inhibits the phosphorylation of STATs. This prevents binding of STATs to DNA sequences on a variety of STAT-responsive gene promoters, which may result in the inhibition of both STAT-mediated transcription and tumor cell proliferation. STATs are constitutively activated in a variety of cancers and play a key role in tumor cell proliferation.

单词	STAT inhibitor OPB-111077
释义	STAT inhibitor OPB-111077 An orally bioavailable inhibitor of one or more signal transducer and activator of transcription (STAT) protein(s), with potential antineoplastic activity. Upon oral administration, OPB-111077 binds to and inhibits the phosphorylation of STATs. This prevents binding of STATs to DNA sequences on a variety of STAT-responsive gene promoters, which may result in the inhibition of both STAT-mediated transcription and tumor cell proliferation. STATs are constitutively activated in a variety of cancers and play a key role in tumor cell proliferation.
随便看	cold contaminant-free iobenguane I 131 COLD-fX cold ischemia cold ischemia time cold knife cone biopsy cold knife conization cold nodule colectomy coleoptile colesevelam hydrochloride colitis collagen collagen collagen/aloe vera/vitamin E/lidocaine topical hydrogel collagenase collagen disease collarbone collecting duct collecting duct collective patient perspective collenchyma cell colloidal gold-bound tumor necrosis factor colloidal oatmeal cream coloanal anastomosis coloanal pull-through