Stage III gallbladder cancer is divided into stages IIIA and IIIB. In stage IIIA, cancer has spread through the thin layers of tissue that cover the gallbladder and/or to the liver and/or to one nearby organ (such as the stomach, small intestine, colon, pancreas, or bile ducts outside the liver). In stage IIIB, cancer has spread to nearby lymph nodes and (1) beyond the inner layer of the gallbladder to a layer of tissue with blood vessels or to the muscle layer; or (2) beyond the muscle layer to the connective tissue around the muscle; or (3) through the thin layers of tissue that cover the gallbladder and/or to the liver and/or to one nearby organ (such as the stomach, small intestine, colon, pancreas, or bile ducts outside the liver).