Stage II is divided into stages IIA and IIB, depending on where the cancer has spread. In stage IIA, cancer has spread (1) into the muscle layer or the connective tissue layer of the esophagus wall, and the cancer cells are grade 1. Grade 1 cancer cells look more like normal cells under a microscope and grow and spread more slowly than grade 2 and 3 cancer cells. The tumor is in either the upper or middle esophagus; or (2) into the muscle layer or the connective tissue layer of the esophagus wall, and the cancer cells are grade 2 and 3. Grade 2 and 3 cancer cells look more abnormal under a microscope and grow and spread more quickly than grade 1 cancer cells. The tumor is in the lower esophagus or it is not known where the tumor is.