The frequency with which a test yields a true negative result among individuals who do not have the disease or the gene mutation in question. A test with high specificity has a low false-positive rate and thus does a good job of correctly classifying unaffected individuals. or When referring to a medical test, specificity refers to the percentage of people who test negative for a specific disease among a group of people who do not have the disease. No test is 100% specific because some people who do not have the disease will test positive for it (false positive).