An oral spray containing soy phospholipid and glycerol dioleate, with protective, analgesic and anti-mucositic activities. Upon spraying onto the oral mucosal surface and contact with saliva, the soy lecithin/glycerol dioleate-based oral spray forms a gel and adheres to the mucosal surfaces thereby forming a lipid film. This provides a protective barrier and an analgesic effect within the oral cavity. In addition, the lipid barrier prevents bacterial growth at affected areas thereby decreasing infection risk. Check for active clinical trialsusing this agent.